Parsimonious immune-response endotypes and global outcome in patients with traumatic brain injury.

Samanta RJ, Chiollaz AC, Needham E, Yue JK, Helmy A, Zanier ER, Wang KKW, Kobeissy F, Posti JP, Summers C, Manley GT, Maas AI, Tenovuo O, Sanchez JC, Menon DK; TRACK-TBI investigators and participants; CENTER-TBI investigators and participants. EBioMedicine. 2024 Sep 17;108:105310. PMID 39293212. <<PubMed>>

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Prior Traumatic Brain Injury Is A Risk Factor for In-Hospital Mortality In Moderate to Severe Traumatic Brain Injury: A TRACK-TBI Cohort Study.

Yue JK, Etemad LL, Elguindy MM, van Essen TA, Belton PJ, Nelson LD, McCrea MA, Vreeburg RJG, Gotthardt CJ, Tracey JX, Krishnan N, Halabi C, Eagle SR, Korley FK, Robertson CS, Duhaime AC, Satris GG, Tarapore PE, Huang MC, Madhok DY, Giacino JT, Mukherjee P, Yuh EL, Valadka AB, Puccio AM, Okonkwo DO, Sun X, Jain S, Manley GT, DiGiorgio AM; TRACK-TBI Investigators. Trauma Surg Acute Care Open. 2024 Jul 24;9(1):e001501. PMID 39081460. <<PubMed>>

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Clinical and Imaging Characteristics, Care Pathways, and Outcomes of Traumatic Epidural Hematomas: A Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury Study.

Pisică D, Volovici V, Yue JK, van Essen TA, den Boogert HF, Vande Vyvere T, Haitsma I, Nieboer D, Markowitz AJ, Yuh EL, Steyerberg EW, Peul WC, Dirven CMF, Menon DK, Manley GT, Maas AIR, Lingsma HF; CENTER-TBI Participants and Investigators. Neurosurgery. 2024 May 21. PMID 38771081. <<PubMed>>

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Performance of the IMPACT and CRASH prognostic models for traumatic brain injury in a contemporary multicenter cohort: A TRACK-TBI Study.

Yue JK, Lee YM, Sun X, van Essen TA, Elguindy MM, Belton PJ, Pisică D, Mikolic A, Deng H, Kanter JH, McCrea MA, Bodien YG, Satris GG, Wong JC, Ambati VS, Grandhi R, Puccio AM, Mukherjee P, Valadka AB, Tarapore PE, Huang MC, DiGiorgio AM, Markowitz AJ, Yuh EL, Okonkwo DO, Steyerberg EW, Lingsma HF, Menon DK, Maas AIR, Jain S, Manley GT; The TRACK-TBI Investigators. J Neurosurg. 2024 Mar 15;141(2):417-429. PMID 38489823. <<PubMed>>

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Isolated Traumatic Subarachnoid Hemorrhage on Head Computed Tomography Scan May Not Be Isolated: A TRACK-TBI Study.

Yue JK, Yuh EL, Elguindy MM, Sun X, Van Essen TA, Deng H, Belton PJ, Satris GG, Wong JC, Valadka A, Korley FK, Robertson CS, McCrea M, Stein MB, Diaz-Arrastia R, Wang KKW, Temkin N, DiGiorgio AM, Tarapore PE, Huang MC, Markowitz A, Puccio AM, Mukherjee P, Okonkwo DO, Jain S, Manley GT; TRACK-TBI Investigators. J Neurotrauma. 2024 Jun;41(11-12):1310-1322. PMID 38450561. <<PubMed>>

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Association of Biomarkers of Neuronal Injury and Inflammation With Insomnia Trajectories After Traumatic Brain Injury: A TRACK-TBI Study.

Werner JK, Albrecht J, Capaldi VF, Jain S, Sun X, Mukherjee P, Williams SG, Collen J, Diaz-Arrastia R, Manley GT, Krystal AD, Wickwire E; TRACK-TBI Investigators. Neurology. 2024 Apr 23;102(8):e209269. PMID 38547447. <<PubMed>>

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MaPPeRTrac: A Massively Parallel, Portable, and Reproducible Tractography Pipeline.

Cai LT, Moon J, Camacho PB, Anderson AT, Chwa WJ, Sutton BP, Markowitz AJ, Palacios EM, Rodriguez A, Manley GT, Shankar S, Bremer PT, Mukherjee P, Madduri RK; TRACK-TBI Investigators. Neuroinformatics. 2024 Apr;22(2):177-191. PMID 38446357. <<PubMed>>

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Diagnostic Utility of Glial Fibrillary Acidic Protein Beyond 12 Hours After Traumatic Brain Injury: A TRACK-TBI Study.

Puccio AM, Yue JK, Korley FK, Okonkwo DO, Diaz-Arrastia R, Yuh EL, Ferguson AR, Mukherjee P, Wang KKW, Taylor SR, Deng H, Markowitz AJ, Sun X, Jain S, Manley GT; TRACK-TBI Investigators. J Neurotrauma. 2024 Jun;41(11-12):1353-1363. PMID 38251868. <<PubMed>>

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Profiles of Cognitive Functioning at 6 Months After Traumatic Brain Injury Among Patients in Level I Trauma Centers: A TRACK-TBI Study.

Bryant AM, Rose NB, Temkin NR, Barber JK, Manley GT, McCrea MA, Nelson LD; TRACK-TBI Investigators. JAMA Netw Open. 2023 Dec 1;6(12):e2349118. PMID 38147333. <<PubMed>>

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Clinical Outcomes After Traumatic Brain Injury and Exposure to Extracranial Surgery: A TRACK-TBI Study.

Roberts CJ, Barber J, Temkin NR, Dong A, Robertson CS, Valadka AB, Yue JK, Markowitz AJ, Manley GT, Nelson LD; TRACK-TBI Investigators. JAMA Surg. 2023 Dec 13:e236374. PMID 38091011. <<PubMed>>

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Data-driven distillation and precision prognosis in traumatic brain injury with interpretable machine learning.

Tritt A, Yue JK, Ferguson AR, Torres Espin A, Nelson LD, Yuh EL, Markowitz AJ, Manley GT, Bouchard KE; TRACK-TBI Investigators. Sci Rep. 2023 Dec 1;13(1):21200. PMID 38040784. <<PubMed>>

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Association of Early Dexmedetomidine Utilization With Clinical and Functional Outcomes Following Moderate-Severe Traumatic Brain Injury: A Transforming Clinical Research and Knowledge in Traumatic Brain Injury Study.

Liu SY, Kelly-Hedrick M, Temkin N, Barber J, Komisarow J, Hatfield J, Ohnuma T, Manley G, Treggiari MM, Colton K, Vavilala MS, Grandhi R, Laskowitz DT, Mathew JP, Hernandez A, James ML, Raghunathan K, Goldstein B, Markowitz A, Krishnamoorthy V; Transforming Clinical Research and Knowledge in TBI (TRACK-TBI) Investigators. Crit Care Med. 2024 Apr 1;52(4):607-617. PMID 37966330. <<PubMed>>

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Longitudinal Recovery Following Repetitive Traumatic Brain Injury.

Etemad LL, Yue JK, Barber J, Nelson LD, Bodien YG, Satris GG, Belton PJ, Madhok DY, Huie JR, Hamidi S, Tracey JX, Coskun BC, Wong JC, Yuh EL, Mukherjee P, Markowitz AJ, Huang MC, Tarapore PE, Robertson CS, Diaz-Arrastia R, Stein MB, Ferguson AR, Puccio AM, Okonkwo DO, Giacino JT, McCrea MA, Manley GT, Temkin NR, DiGiorgio AM; TRACK-TBI Investigators. JAMA Netw Open. 2023 Sep 5;6(9):e2335804. PMID 37751204. <<PubMed>>

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Prevalence of and Risk Factors for Post-traumatic Headache in Civilian Patients After Mild Traumatic Brain Injury: A TRACK-TBI Study.

Ashina H, Dodick DW, Barber J, Temkin NR, Chong CD, Adler JS, Stein KS, Schwedt TJ, Manley GT; TRACK-TBI Investigators. Mayo Clin Proc. 2023 Oct;98(10):1515-1526. PMID 37480909. <<PubMed>>

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Predicting Functional Dependency in Patients with Disorders of Consciousness: A TBI-Model Systems and TRACK-TBI Study.

Snider SB, Temkin NR, Barber J, Edlow BL, Giacino JT, Hammond FM, Izzy S, Kowalski RG, Markowitz AJ, Rovito CA, Shih SL, Zafonte RD, Manley GT, Bodien YG; TRACK-TBI investigators. Ann Neurol. 2023 Dec;94(6):1008-1023. PMID 37470289. <<PubMed>>

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Association of obesity with mild traumatic brain injury symptoms, inflammatory profile, quality of life and functional outcomes: a TRACK-TBI Study.

Eagle SR, Puccio AM, Nelson LD, McCrea M, Giacino J, Diaz-Arrastia R, Conkright W, Jain S, Sun X, Manley G, Okonkwo DO; TRACK-TBI Investigators. J Neurol Neurosurg Psychiatry. 2023 Jun 27:jnnp-2023-331562. PMID 37369556. <<PubMed>>

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Associations of Microvascular Injury-Related Biomarkers With Traumatic Brain Injury Severity and Outcomes: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Pilot Study.

Schneider ALC, Huie JR, Jain S, Sun X, Ferguson AR, Lynch C, Yue JK, Manley GT, Wang KKW, Sandsmark DK, Campbell C, Diaz-Arrastia R. J Neurotrauma. 2023 Aug;40(15-16):1625-1637. PMID 37021339. <<PubMed>>

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Neuroinflammatory Biomarkers for Traumatic Brain Injury Diagnosis and Prognosis: A TRACK-TBI Pilot Study.

Yue JK, Kobeissy FH, Jain S, Sun X, Phelps RRL, Korley FK, Gardner RC, Ferguson AR, Huie JR, Schneider ALC, Yang Z, Xu H, Lynch CE, Deng H, Rabinowitz M, Vassar MJ, Taylor SR, Mukherjee P, Yuh EL, Markowitz AJ, Puccio AM, Okonkwo DO, Diaz-Arrastia R, Manley GT, Wang KKW. Neurotrauma Rep. 2023 Mar 24;4(1):171-183. PMID 36974122. <<PubMed>>

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Neuroworsening in the Emergency Department Is a Predictor of Traumatic Brain Injury Intervention and Outcome: A TRACK-TBI Pilot Study.

Yue JK, Krishnan N, Kanter JH, Deng H, Okonkwo DO, Puccio AM, Madhok DY, Belton PJ, Lindquist BE, Satris GG, Lee YM, Umbach G, Duhaime AC, Mukherjee P, Yuh EL, Valadka AB, DiGiorgio AM, Tarapore PE, Huang MC, Manley GT; TRACK-TBI Investigators. J Clin Med. 2023 Mar 3;12(5):2024. PMID 36902811. <<PubMed>>

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Polygenic risk for mental disorders as predictors of posttraumatic stress disorder after mild traumatic brain injury.

Stein MB, Jain S, Parodi L, Choi KW, Maihofer AX, Nelson LD, Mukherjee P, Sun X, He F, Okonkwo DO, Giacino JT, Korley FK, Vassar MJ, Robertson CS, McCrea MA, Temkin N, Markowitz AJ, Diaz-Arrastia R, Rosand J, Manley GT; TRACK-TBI Investigators. Transl Psychiatry. 2023 Jan 25;13(1):24. PMID 36693822. <<PubMed>>

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Effects of age and time since injury on traumatic brain injury blood biomarkers: a TRACK-TBI study.

Gardner RC, Puccio AM, Korley FK, Wang KKW, Diaz-Arrastia R, Okonkwo DO, Puffer RC, Yuh EL, Yue JK, Sun X, Taylor SR, Mukherjee P, Jain S, Manley GT; TRACK-TBI Investigators. Brain Commun. 2022 Dec 1;5(1):fcac316. PMID 36642999. <<PubMed>>

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Dizziness After Traumatic Brain Injury: A Prospective TRACK-TBI Analysis of Risk Factors, Quality of Life, and Neurocognitive Effects.

Chae R, Barber J, Temkin NR, Sharon JD; TRACK-TBI Investigators. Otol Neurotol. 2022 Dec 1;43(10):e1148-e1156. PMID 36201561. <<PubMed>>

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Traumatic brain injury: progress and challenges in prevention, clinical care, and research.

Maas AIR, Menon DK, Manley GT, Abrams M, Åkerlund C, Andelic N, Aries M, Bashford T, Bell MJ, Bodien YG, Brett BL, Büki A, Chesnut RM, Citerio G, Clark D, Clasby B, Cooper DJ, Czeiter E, Czosnyka M, Dams-O'Connor K, De Keyser V, Diaz-Arrastia R, Ercole A, van Essen TA, Falvey É, Ferguson AR, Figaji A, Fitzgerald M, Foreman B, Gantner D, Gao G, Giacino J, Gravesteijn B, Guiza F, Gupta D, Gurnell M, Haagsma JA, Hammond FM, Hawryluk G, Hutchinson P, van der Jagt M, Jain S, Jain S, Jiang JY, Kent H, Kolias A, Kompanje EJO, Lecky F, Lingsma HF, Maegele M, Majdan M, Markowitz A, McCrea M, Meyfroidt G, Mikolić A, Mondello S, Mukherjee P, Nelson D, Nelson LD, Newcombe V, Okonkwo D, Orešič M, Peul W, Pisică D, Polinder S, Ponsford J, Puybasset L, Raj R, Robba C, Røe C, Rosand J, Schueler P, Sharp DJ, Smielewski P, Stein MB, von Steinbüchel N, Stewart W, Steyerberg EW, Stocchetti N, Temkin N, Tenovuo O, Theadom A, Thomas I, Espin AT, Turgeon AF, Unterberg A, Van Praag D, van Veen E, Verheyden J, Vyvere TV, Wang KKW, Wiegers EJA, Williams WH, Wilson L, Wisniewski SR, Younsi A, Yue JK, Yuh EL, Zeiler FA, Zeldovich M, Zemek R; InTBIR Participants and Investigators. Lancet Neurol. 2022 Nov;21(11):1004-1060. PMID 36183712. <<PubMed>>

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Emotional Resilience Predicts Preserved White Matter Microstructure Following Mild Traumatic Brain Injury.

Cai LT, Brett BL, Palacios EM, Yuh EL, Bourla I, Wren-Jarvis J, Wang Y, Mac Donald C, Diaz-Arrastia R, Giacino JT, Okonkwo DO, Levin HS, Robertson CS, Temkin N, Markowitz AJ, Manley GT, Stein MB, McCrea MA, Zafonte RD, Nelson LD, Mukherjee P; TRACK-TBI Investigators. Biol Psychiatry Cogn Neurosci Neuroimaging. 2022 Sep 21:S2451-9022(22)00231-2. PMID 36152948. <<PubMed>>

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Feasibility and Utility of a Flexible Outcome Assessment Battery for Longitudinal Traumatic Brain Injury Research: A TRACK-TBI Study.

Bodien YG, Barber J, Taylor SR, Boase K, Corrigan JD, Dikmen S, Gardner RC, Kramer JH, Levin H, Machamer J, McAllister T, Nelson LD, Ngwenya LB, Sherer M, Stein MB, Vassar M, Whyte J, Yue JK, Markowitz A, McCrea MA, Manley GT, Temkin N, Giacino JT. J Neurotrauma. 2023 Feb;40(3-4):337-348. PMID 36097759. <<PubMed>>

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Outcomes in Patients With Mild Traumatic Brain Injury Without Acute Intracranial Traumatic Injury.

Madhok DY, Rodriguez RM, Barber J, Temkin NR, Markowitz AJ, Kreitzer N, Manley GT, and the TRACK-TBI Investigators. JAMA Netw Open. 2022 Aug 1;5(8):e2223245. PMID 35976650. <<PubMed>> 

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Diffusion Tensor Imaging Reveals Elevated Diffusivity of White Matter Microstructure that Is Independently Associated with Long-Term Outcome after Mild Traumatic Brain Injury: A TRACK-TBI Study.

Palacios EM, Yuh EL, Mac Donald CL, Vassar MJ, Diaz-Arrastia R, Giacino JT, Okonkwo DO, Robertson CS, Stein MB, Temkin N, McCrea MA, Levin HS, Markowitz AJ, Jain S, Manley GT, Mukherjee P; TRACK-TBI Investigators.  J Neurotrauma. 2022 Jul 18. <<PubMed>>

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Prognostic value of day-of-injury plasma GFAP and UCH-L1 concentrations for predicting functional recovery after traumatic brain injury in patients from the US TRACK-TBI cohort: an observational cohort study.

Korley FK, Jain S, Sun X, Puccio AM, Yue JK, Gardner RC, Wang KKW, Okonkwo DO, Yuh EL, Mukherjee P, Nelson LD, Taylor SR, Markowitz AJ, Diaz-Arrastia R, Manley GT; TRACK-TBI Study Investigators. Lancet Neurol. 2022 Sep;21(9):803-813. PMID 35963263. <<PubMed>>

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Employment and Economic Outcomes of Participants With Mild Traumatic Brain Injury in the TRACK-TBI Study.

Gaudette É, Seabury SA, Temkin N, Barber J, DiGiorgio AM, Markowitz AJ, Manley GT; TRACK-TBI Investigators. JAMA Netw Open. 2022 Jun 1;5(6):e2219444. PMID 35767257. <<PubMed>>

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Association of Day-of-Injury Serum Glial Fibrillary Acidic Protein Concentration and Six-Month Posttraumatic Stress Disorder in Patients with Mild Traumatic Brain Injury.

Kulbe JR, Jain S, Nelson LD, Korley FK, Mukherjee P, Sun X, Okonkwo DO, Giacino JT, Vassar M, Robertson C, McCrea MA, Wang KKW, Temkin N, Mac Donald C, Taylor S, Ferguson AR, Markowitz AJ, Diaz-Arrastia R, Manley GT, Stein MB, and the TRACK-TBI Investigators. Neuropsychopharmacology. 2022 Dec;47(13):2300-2308. PMID 35717463. <<PubMed>>

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Outcome Prediction in Patients with Severe Traumatic Brain Injury Using Deep Learning from Head CT Scans.

Pease M, Arefan D, Barber J, Yuh E, Puccio A, Hochberger K, Nwachuku E, Roy S, Casillo S, Temkin N, Okonkwo DO, Wu S; TRACK-TBI Investigators. Radiology. 2022 Aug;304(2):385-394. PMID 35471108. <<PubMed>>

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Improving the Precision of the Glasgow Outcome Scale-Extended Using Item Response Theory: A TRACK-TBI Study.

Magnus BE, Balsis S, Giacino JT, McCrea MA, Temkin NR, Whyte J, Manley GT, Nelson LD; TRACK-TBI Investigators. J Neurotrauma. 2022 Jun;39(11-12):870-878. PMID 35317604. <<PubMed>>

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A genome-wide association study of outcome from traumatic brain injury.

Kals M, Kunzmann K, Parodi L, Radmanesh F, Wilson L, Izzy S, Anderson CD, Puccio AM, Okonkwo DO, Temkin N, Steyerberg EW, Stein MB, Manley GT, Maas AIR, Richardson S, Diaz-Arrastia R, Palotie A, Ripatti S, Rosand J, Menon DK; Genetic Associations In Neurotrauma (GAIN) Consortium (with contribution from the CENTER-TBI, TRACK-TBI, CABI, MGB, and TBIcare studies). EBioMedicine. 2022 Mar;77:103933. PMID 35301180. <<PubMed>>

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Life After Mild Traumatic Brain Injury: Widespread Structural Brain Changes Associated With Psychological Distress Revealed With Multimodal Magnetic Resonance Imaging.

Sibilia F, Custer RM, Irimia A, Sepehrband F, Toga AW, Cabeen RP; TRACK-TBI Investigators. Biol Psychiatry Glob Open Sci. 2022 Mar 16;3(3):374-385. PMID 37519474. <<PubMed>>

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Cognitive Outcome 1 Year After Mild Traumatic Brain Injury: Results From the TRACK-TBI Study.

Schneider ALC, Huie JR, Boscardin WJ, Nelson L, Barber JK, Yaffe K, Diaz-Arrastia R, Ferguson AR, Kramer J, Jain S, Temkin N, Yuh E, Manley GT, Gardner RC; TRACK-TBI Investigators. Neurology. 2022 Mar 22;98(12):e1248-e1261. PMID 35173018. <<PubMed>>

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Trajectories of Insomnia in Adults After Traumatic Brain Injury.

Wickwire EM, Albrecht JS, Capaldi VF 2nd, Jain SO, Gardner RC, Werner JK, Mukherjee P, McKeon AB, Smith MT, Giacino JT, Nelson LD, Williams SG, Collen J, Sun X, Schnyer DM, Markowitz AJ, Manley GT, Krystal AD; Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Investigators. JAMA Netw Open. 2022 Jan 4;5(1):e2145310. PMID 35080600. <<PubMed>>

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Symptom Frequency and Persistence in the First Year after Traumatic Brain Injury: A TRACK-TBI Study.

Machamer J, Temkin N, Dikmen S, Nelson LD, Barber J, Hwang P, Boase K, Stein MB, Sun X, Giacino J, McCrea MA, Taylor SR, Jain S, Manley G; TRACK-TBI Investigators. J Neurotrauma. 2022 Mar;39(5-6):358-370. PMID 35078327. <<PubMed>>

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The Case for Optimized Edge-Centric Tractography at Scale.

Moon JY, Mukherjee P, Madduri RK, Markowitz AJ, Cai LT, Palacios EM, Manley GT, Bremer PT. Front Neuroinform. 2022 May 16:16:752471. PMID 35651721. <<PubMed>>

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Incidence and Clinical Impact of Myocardial Injury Following Traumatic Brain Injury: A Pilot TRACK-TBI Study.

Krishnamoorthy V, Manley GT, Jain S, Sun S, Foreman B, Komisarow J, Laskowitz DT, Mathew JP, Hernandez A, James ML, Vavilala MS, Markowitz AJ, Korley FK; TRACK-TBI Investigators. J Neurosurg Anesthesiol. 2022 Apr 1;34(2):233-237. PMID 33901061. <<PubMed>>

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Effect of frailty on 6-month outcome after traumatic brain injury: a multicentre cohort study with external validation.

Galimberti S, Graziano F, Maas AIR, Isernia G, Lecky F, Jain S, Sun X, Gardner RC, Taylor SR, Markowitz AJ, Manley GT, Valsecchi MG, Bellelli G, Citerio G; CENTER-TBI and TRACK-TBI participants and investigators. Lancet Neurol. 2022 Feb;21(2):153-162. PMID 35065038. <<PubMed>>

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Mixture Model Framework for Traumatic Brain Injury Prognosis Using Heterogeneous Clinical and Outcome Data.

Kaplan AD, Cheng Q, Mohan KA, Nelson LD, Jain S, Levin H, Torres-Espin A, Chou A, Huie JR, Ferguson AR, Mccrea M, Giacino J, Sundaram S, Markowitz AJ, Manley GT. IEEE J Biomed Health Inform. 2022 Mar;26(3):1285-1296. PMID 34310331. <<PubMed>>

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Blood-based traumatic brain injury biomarkers - Clinical utilities and regulatory pathways in the United States, Europe and Canada.

Wang KK, Munoz Pareja JC, Mondello S, Diaz-Arrastia R, Wellington C, Kenney K, Puccio AM, Hutchison J, McKinnon N, Okonkwo DO, Yang Z, Kobeissy F, Tyndall JA, Büki A, Czeiter E, Pareja Zabala MC, Gandham N, Berman R. Expert Rev Mol Diagn. 2021 Dec;21(12):1303-1321. PMID 34783274. <<PubMed>>

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Relationship between transdiagnostic dimensions of psychopathology and traumatic brain injury (TBI): A TRACK-TBI study.

Nelson LD, Kramer MD, Joyner KJ, Patrick CJ, Stein MB, Temkin N, Levin HS, Whyte J, Markowitz AJ, Giacino J, Manley GT; TRACK-TBI Investigators. J Abnorm Psychol. 2021 Jul;130(5):423–434. PMID 34110838. <<PubMed>>

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Diagnosing Level of Consciousness: The Limits of the Glasgow Coma Scale Total Score.

Bodien YG, Barra A, Temkin NR, Barber J, Foreman B, Vassar M, Robertson C, Taylor SR, Markowitz AJ, Manley GT, Giacino JT, Edlow BL; TRACK-TBI Investigators. J Neurotrauma. 2021 Dec;38(23):3295-3305. PMID 34605668. <<PubMed>>

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Association of Posttraumatic Epilepsy With 1-Year Outcomes After Traumatic Brain Injury.

Burke J, Gugger J, Ding K, Kim JA, Foreman B, Yue JK, Puccio AM, Yuh EL, Sun X, Rabinowitz M, Vassar MJ, Taylor SR, Winkler EA, Deng H, McCrea M, Stein MB, Robertson CS, Levin HS, Dikmen S, Temkin NR, Barber J, Giacino JT, Mukherjee P, Wang KKW, Okonkwo DO, Markowitz AJ, Jain S, Lowenstein D, Manley GT, Diaz-Arrastia R; TRACK-TBI Investigators; Badjatia N, Duhaime AC, Feeser VR, Gaudette E, Gopinath S, Keene CD, Korley FK, Madden C, Merchant R, Schnyer D, Zafonte R. JAMA Netw Open. 2021 Dec 1;4(12):e2140191. PMID 34964854. <<PubMed>>

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Comparing the Quality of Life after Brain Injury-Overall Scale and Satisfaction with Life Scale as Outcome Measures for Traumatic Brain Injury Research.

Kreitzer N, Jain S, Young JS, Sun X, Stein MB, McCrea MA, Levin HS, Giacino JT, Markowitz AJ, Manley GT, Nelson LD; Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Investigators. J Neurotrauma. 2021 Dec;38(23):3352-3363. PMID 34435894. <<PubMed>>

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Prognostic Value of Hemorrhagic Brainstem Injury on Early Computed Tomography: A TRACK-TBI Study.

Williams JR, Nieblas-Bedolla E, Feroze A, Young C, Temkin NR, Giacino JT, Okonkwo DO, Manley GT, Barber J, Durfy S, Markowitz AJ, Yuh EL, Mukherjee P, Mac Donald CL; and The Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Investigators. Neurocrit Care. 2021 Oct;35(2):335-346. PMID 34309784. <<PubMed>>

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Interrater Reliability of National Institutes of Health Traumatic Brain Injury Imaging Common Data Elements for Brain Magnetic Resonance Imaging in Mild Traumatic Brain Injury.

Rincon SP, Mukherjee P, Levin HS, Temkin NR, Mac Donald CL, Krainak DM, Sun X, Jain S, Taylor SR, Markowitz AJ, Kumar A, Manley GT, Yuh EL; TRACK-TBI Investigators. J Neurotrauma. 2021 Oct 15;38(20):2831-2840. PMID 34275326. <<PubMed>>

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Association of Vasopressor Choice with Clinical and Functional Outcomes Following Moderate to Severe Traumatic Brain Injury: A TRACK-TBI Study.

Toro C, Temkin N, Barber J, Manley G, Jain S, Ohnuma T, Komisarow J, Foreman B, Korley FK, Vavilala MS, Laskowitz DT, Mathew JP, Hernandez A, Sampson J, James ML, Goldstein BA, Markowitz AJ, Krishnamoorthy V; TRACK-TBI Investigators. Neurocrit Care. 2022 Feb;36(1):180-191. PMID 34341913. <<PubMed>>

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Pathological Computed Tomography Features Associated With Adverse Outcomes After Mild Traumatic Brain Injury: A TRACK-TBI Study With External Validation in CENTER-TBI.

Yuh EL, Jain S, Sun X, Pisica D, Harris MH, Taylor SR, Markowitz AJ, Mukherjee P, Verheyden J, Giacino JT, Levin HS, McCrea M, Stein MB, Temkin NR, Diaz-Arrastia R, Robertson CS, Lingsma HF, Okonkwo DO, Maas AIR, Manley GT; TRACK-TBI Investigators for the CENTER-TBI Investigators. JAMA Neurol. 2021 Sep 1;78(9):1137-1148. PMID 34279565. <<PubMed>>

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Functional Outcomes Over the First Year After Moderate to Severe Traumatic Brain Injury in the Prospective, Longitudinal TRACK-TBI Study.

McCrea MA, Giacino JT, Barber J, Temkin NR, Nelson LD, Levin HS, Dikmen S, Stein M, Bodien YG, Boase K, Taylor SR, Vassar M, Mukherjee P, Robertson C, Diaz-Arrastia R, Okonkwo DO, Markowitz AJ, Manley GT; TRACK-TBI Investigators. JAMA Neurol. 2021 Aug 1;78(8):982-992. PMID 34228047. <<PubMed>>

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Latent Profile Analysis of Neuropsychiatric Symptoms and Cognitive Function of Adults 2 Weeks After Traumatic Brain Injury: Findings From the TRACK-TBI Study.

Brett BL, Kramer MD, Whyte J, McCrea MA, Stein MB, Giacino JT, Sherer M, Markowitz AJ, Manley GT, Nelson LD; TRACK-TBI Investigators. JAMA Netw Open. 2021 Mar 1;4(3):e213467. PMID 33783510. <<PubMed>>

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Tractography-Pathology Correlations in Traumatic Brain Injury: A TRACK-TBI Study.

Nolan AL, Petersen C, Iacono D, Mac Donald CL, Mukherjee P, van der Kouwe A, Jain S, Stevens A, Diamond BR, Wang R, Markowitz AJ, Fischl B, Perl DP, Manley GT, Keene CD, Diaz-Arrastia R, Edlow BL; TRACK-TBI Investigators. J Neurotrauma. 2021 Jun 15;38(12):1620-1631. PMID 33412995. <<PubMed>>

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Smaller Regional Brain Volumes Predict Posttraumatic Stress Disorder at 3 Months After Mild Traumatic Brain Injury.

Stein MB, Yuh E, Jain S, Okonkwo DO, Mac Donald CL, Levin H, Giacino JT, Dikmen S, Vassar MJ, Diaz-Arrastia R, Robertson CS, Nelson LD, McCrea M, Sun X, Temkin N, Taylor SR, Markowitz AJ, Manley GT, Mukherjee P; TRACK-TBI Investigators. Biol Psychiatry Cogn Neurosci Neuroimaging. 2021 Mar;6(3):352-359. PMID 33386283. <<PubMed>>

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Central Curation of Glasgow Outcome Scale-Extended Data: Lessons Learned from TRACK-TBI.

Boase K, Machamer J, Temkin NR, Dikmen S, Wilson L, Nelson LD, Barber J, Bodien YG, Giacino JT, Markowitz AJ, McCrea MA, Satris G, Stein MB, Taylor SR, Manley GT; TRACK-TBI Investigators. J Neurotrauma. 2021 Sep 1;38(17):2419-2434. PMID 33832330. <<PubMed>>

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A Manual for the Glasgow Outcome Scale-Extended (GOSE) Interview.

Wilson L, Boase K, Nelson LD, Temkin NR, Giacino JT, Markowitz AJ, Maas A, Menon DK, Teasdale G, Manley GT. J Neurotrauma. 2021 Sep 1;38(17):2435-2446. PMID 33740873. <<PubMed>>

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Letter to the Editor. Discrepancies in national databases for TBI estimates.

Madhok DY, Hsia RY, Manley GT. J Neurosurg. 2021 Mar 19:1-2. PMID 33740762. <<PubMed>>

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Comparison of GFAP and UCH-L1 Measurements from Two Prototype Assays: The Abbott i-STAT and ARCHITECT Assays.

Korley FK, Datwyler SA, Jain S, Sun X, Beligere G, Chandran R, Marino JA, McQuiston B, Zhang H, Caudle KL, Wang KKW, Puccio AM, Okonkwo DO, Yue JK, Taylor SR, Markowitz A, Manley GT, Diaz-Arrastia R. Neurotrauma Rep. 2021 Apr 7;2(1):193-199. PMID 33937911. <<PubMed>>

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Association of Sex and Age With Mild Traumatic Brain Injury-Related Symptoms: A TRACK-TBI Study.

Levin HS, Temkin NR, Barber J, Nelson LD, Robertson C, Brennan J, Stein MB, Yue JK, Giacino JT, McCrea MA, Diaz-Arrastia R, Mukherjee P, Okonkwo DO, Boase K, Markowitz AJ, Bodien Y, Taylor S, Vassar MJ, Manley GT; TRACK-TBI Investigators. JAMA Netw Open. 2021 Apr 1;4(4):e213046. PMID 33822070. <<PubMed>>

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High-Sensitivity C-Reactive Protein is a Prognostic Biomarker of Six-Month Disability after Traumatic Brain Injury: Results from the TRACK-TBI Study.

Xu LB, Yue JK, Korley F, Puccio AM, Yuh EL, Sun X, Rabinowitz M, Vassar MJ, Taylor SR, Winkler EA, Puffer RC, Deng H, McCrea M, Stein MB, Robertson CS, Levin HS, Dikmen S, Temkin NR, Giacino JT, Mukherjee P, Wang KKW, Okonkwo DO, Markowitz AJ, Jain S, Manley GT, Diaz-Arrastia R; TRACK-TBI Investigators. J Neurotrauma. 2021 Apr 1;38(7):918-927. PMID 33161875. <<PubMed>>

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Validity of the Brief Test of Adult Cognition by Telephone in Level 1 Trauma Center Patients Six Months Post-Traumatic Brain Injury: A TRACK-TBI Study.

Nelson LD, Barber JK, Temkin NR, Dams-O'Connor K, Dikmen S, Giacino JT, Kramer MD, Levin HS, McCrea MA, Whyte J, Bodien YG, Yue JK, Manley GT; British Neurosurgical Trainee Research Collaborative (BNTRC). J Neurotrauma. 2021 Apr 15;38(8):1048-1059. PMID 33107388. <<PubMed>>

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Point-of-Care Platform Blood Biomarker Testing of Glial Fibrillary Acidic Protein versus S100 Calcium-Binding Protein B for Prediction of Traumatic Brain Injuries: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury Study.

Okonkwo DO, Puffer RC, Puccio AM, Yuh EL, Yue JK, Diaz-Arrastia R, Korley FK, Wang KKW, Sun X, Taylor SR, Mukherjee P, Markowitz AJ, Jain S, Manley GT; Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Investigators. J Neurotrauma. 2020 Dec 1;37(23):2460-2467. PMID 32854584. <<PubMed>>

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Risk Factors for Suicidal Ideation Following Mild Traumatic Brain Injury: A TRACK-TBI Study.

Campbell-Sills L, Jain S, Sun X, Fisher LB, Agtarap SD, Dikmen S, Nelson LD, Temkin N, McCrea M, Yuh E, Giacino JT, Manley GT, Stein MB; TRACK-TBI Investigators. J Head Trauma Rehabil. J Head Trauma Rehabil. 2021 Jan-Feb 01;36(1):E30-E39. PMID 32769835. <<PubMed>>

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Polytrauma Is Associated with Increased Three- and Six-Month Disability after Traumatic Brain Injury: A TRACK-TBI Pilot Study.

Yue JK, Satris GG, Dalle Ore CL, Huie JR, Deng H, Winkler EA, Lee YM, Vassar MJ, Taylor SR, Schnyer DM, Lingsma HF, Puccio AM, Yuh EL, Mukherjee P, Valadka AB, Ferguson AR, Markowitz AJ, Okonkwo DO, Manley GT. Neurotrauma Rep. 2020 Jul 23;1(1):32-41. PMID 34223528. <<PubMed>>

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Satisfaction with Life after Mild Traumatic Brain Injury: A TRACK-TBI Study.

Agtarap SD, Campbell-Sills L, Jain S, Sun X, Dikmen S, Levin H, McCrea MA, Mukherjee P, Nelson LD, Temkin N, Yuh EL, Giacino JT, Manley GT, Stein MB; TRACK-TBI Investigators. J Neurotrauma. 2021 Mar;38(5):546-554. PMID 33107371. <<PubMed>>

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The evolution of white matter microstructural changes after mild traumatic brain injury: A longitudinal DTI and NODDI study.

Palacios EM, Owen JP, Yuh EL, Wang MB, Vassar MJ, Ferguson AR, Diaz-Arrastia R, Giacino JT, Okonkwo DO, Robertson CS, Stein MB, Temkin N, Jain S, McCrea M, MacDonald CL, Levin HS, Manley GT, Mukherjee P; TRACK-TBI Investigators. Sci Adv. 2020 Aug 7;6(32):eaaz6892. PMID 32821816. <<PubMed>>

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Clinical Predictors of 3- and 6-Month Outcome for Mild Traumatic Brain Injury Patients with a Negative Head CT Scan in the Emergency Department: A TRACK-TBI Pilot Study.

Madhok DY, Yue JK, Sun X, Suen CG, Coss NA, Jain S, Manley GT, The TRACK-TBI Investigators. Brain Sci. 2020 May 1;10(5):269. PMID 32369967. <<PubMed>>

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Substance use on admission toxicology screen is associated with peri-injury factors and six-month outcome after traumatic brain injury: A TRACK-TBI Pilot study.

Yue JK, Phelps RRL, Winkler EA, Deng H, Upadhyayula PS, Vassar MJ, Madhok DY, Schnyer DM, Puccio AM, Lingsma HF, Yuh EL, Mukherjee P, Valadka AB, Okonkwo DO, Manley GT; TRACK-TBI Investigators. J Clin Neurosci. 2020 May;75:149-156. PMID 32173156. <<PubMed>>

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Biomarkers for Traumatic Brain Injury: Data Standards and Statistical Considerations.

Huie JR, Mondello S, Lindsell CJ, Antiga L, Yuh EL, Zanier ER, Masson S, Rosario BL, Ferguson AR; Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Investigators, Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Participants and Investigators. J Neurotrauma. 2021 Sep 15;38(18):2514-2529. PMID 32046588. <<PubMed>>

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Statistical Guidelines for Handling Missing Data in Traumatic Brain Injury Clinical Research.

Nielson JL, Cooper SR, Seabury SA, Luciani D, Fabio A, Temkin NR, Ferguson AR; TRACK-TBI Investigators. J Neurotrauma. 2021 Sep 15;38(18):2530-2537. PMID 32008424 <<PubMed>>

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Unsupervised Machine Learning Reveals Novel Traumatic Brain Injury Patient Phenotypes with Distinct Acute Injury Profiles and Long-Term Outcomes.

Folweiler KA, Sandsmark DK, Diaz-Arrastia R, Cohen AS, Masino AJ. J Neurotrauma. 2020 Jun 15;37(12):1431-1444. PMID 32008422. <<PubMed>>

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Common Data Elements: Critical Assessment of Harmonization between Current Multi-Center Traumatic Brain Injury Studies.

Meeuws S, Yue JK, Huijben JA, Nair N, Lingsma HF, Bell MJ, Manley GT, Maas AIR. J Neurotrauma. 2020 Jun 1;37(11):1283-1290. PMID 32000562. <<PubMed>>

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Invariance of the Bifactor Structure of Mild Traumatic Brain Injury (mTBI) Symptoms on the Rivermead Postconcussion Symptoms Questionnaire Across Time, Demographic Characteristics, and Clinical Groups: A TRACK-TBI Study.

Agtarap S, Kramer MD, Campbell-Sills L, Yuh E, Mukherjee P, Manley GT, McCrea MA, Dikmen S, Giacino JT, Stein MB, Nelson LD; TRACK-TBI Investigators. Assessment. 2021 Sep;28(6):1656-1670. PMID 32326739. <<PubMed>>

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Association between plasma GFAP concentrations and MRI abnormalities in patients with CT-negative traumatic brain injury in the TRACK-TBI cohort: a prospective multicentre study.

Yue JK, Yuh EL, Korley FK, Winkler EA, Sun X, Puffer RC, Hansen D, Choy Wm, Taylor SR, Ferguson AR, Huie R, Rabinowitz M, Puccio AM, Mukherjee PM, Vassar MJ, Wang KKW, Diaz-Arrastia R, Okonkwo DO, Jain S, Manley GT; TRACK-TBI Investigators. Lancet Neurol. 2019 Oct;18(10):953-961. PMID 31451409. <<PubMed>>

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The LONI QC System: A Semi-Automated, Web-Based and Freely-Available Environment for the Comprehensive Quality Control of Neuroimaging Data.

Kim H, Irimia A, Hobel SM, Pogosyan M, Tang H, Petrosyan P, Blanco REC, Duffy BA, Zhao L, Crawford KL, Liew SL, Clark K, Law M, Mukherjee P, Manley GT, Van Horn JD, Toga AW. Front Neuroinform. 2019 Aug 28;13:60. PMID 31555116 <<PubMed>>

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Recovery After Mild Traumatic Brain Injury in Patients Presenting to US Level I Trauma Centers: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Study.

Nelson LD, Temkin NR, Dikmen S, Barber J, Giacino JT, Yuh E, Levin HS, McCrea MA, Stein MB, Mukherjee P, Okonkwo DO, Robertson CS, Diaz-Arrastia R, Manley GT; and the TRACK-TBI Investigators. JAMA Neurol. 2019 Sep 1;76(9):1049-1059. PMID 31157856. <<PubMed>>

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Pre-injury Comorbidities Are Associated With Functional Impairment and Post-concussive Symptoms at 3- and 6-Months After Mild Traumatic Brain Injury: A TRACK-TBI Study.

Yue JK, Cnossen MC, Winkler EA, Deng H, Phelps RRL, Coss NA, Sharma S, Robinson CK, Suen CG, Vassar MJ, Schnyer DM, Puccio AM, Gardner RC, Yuh EL, Mukherjee P, Valadka AB, Okonkwo DO, Lingsma HF, Manley GT; TRACK-TBI Investigators. Front Neurol. 2019 Apr 9;10:343. PMID 31024436. <<PubMed>>

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Age and sex-mediated differences in six-month outcomes after mild traumatic brain injury in young adults: A TRACK-TBI study.

Yue JK, Levin HS, Suen CG, Morrissey MR, Runyon SJ, Winkler EA, Puffer RC, Deng H, Robinson CK, Rick JW, Phelps RRL, Sharma S, Taylor SR, Vassar MJ, Cnossen MC, Lingsma HF, Gardner RC, Temkin NR, Barber J, Dikmen SS, Yuh EL, Mukherjee P, Stein MB, Cage TA, Valadka AB, Okonkwo DO, Manley GT; TRACK-TBI Investigators. Neurol Res. 2019 Jul;41(7):609-623. PMID 31007155. <<PubMed>>

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Diagnosing the GOSE: Structural and psychometric properties using item response theory, A TRACK-TBI Pilot Study.

Ranson J, Magnus BE, Temkin N, Dikmen S, Giacino J, Okonkwo DO, Valadka A, Manley GT, Nelson LD; TRACK-TBI Investigators. J Neurotrauma. 2019 Sep 1;36(17):2493-2505. PMID 30907261. <<PubMed>>

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Functional status examination versus Glasgow Outcome Scale Extended as outcome measures in traumatic brain injuries: How do they compare?

Dikmen S, Machamer J, Manley GT, Yuh EL, Nelson LD, Temkin NR; TRACK-TBI Investigators. J Neurotrauma. 2019 Aug 15;36(16):2423-2429. PMID 30827167. <<PubMed>>

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Risk of posttraumatic stress disorder and major depression in civilian patients after mild traumatic brain injury: A TRACK-TBI study.

Stein MB, Jain S, Giacino JT, Levin HS, Dikmen SS, Nelson LD, Vassar MJ, Okonkwo DO, Diaz-Arrastia R, Robertson CS, Mukherjee P, McCrea M, Mac Donald CL, Yue JK, Yuh EL, Sun X, Campbell-Sills L, Temkin NR, Manley GT; TRACK-TBI Investigators. JAMA Psychiatry. 2019 Mar 1;76(3):249-258. PMID 30698636. <<PubMed>>

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The functional status examination in mild traumatic brain injury: A TRACK-TBI Sub-Study.​

Zahniser E, Temkin NR, Machamer J, Barber J, Manley GT, Markowitz AJ, Dikmen SS; TRACK-TBI Investigators. Arch Clin Neuropsychol. 2019 Jan 4. Epub ahead of print. PMID 30608522. <<PubMed>>

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The temporal relationship of mental health problems and functional limitations following mTBI: A TRACK-TBI and TED Study.​

Zahniser E, Nelson LD, Dikmen SS, Machamer JE, Stein MB, Yuh EL, Manley GT, Temkin NR; TRACK-TBI Investigators.​ J Neurotrauma. 2019 Jun;36(11):1786-1793. PMID 30543138. <<PubMed>>

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A comparison of satisfaction with life and the Glasgow Outcome Scale-Extended after traumatic brain injury: An analysis of the TRACK-TBI Pilot study.

Kreitzer NP, Hart KW, Lindsell CJ, Manley GT, Dikmen SS, Ratcliff JJ, Yue JK, Adeoye OM. J Head Tr Rehabil. 2019 May/Jun;34(3):E10-E17. PMID 30499935. <<PubMed>>

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Sleep, sleep disorders, and circadian health following mild traumatic brain injury in adults: Review and research agenda.​ 

Wickwire EM, Schnyer DM, Germain A, Williams SG, Lettieri CJ, McKeon AB, Scharf SM, Stocker R, Albrecht J, Badjatia N, Markowitz AJ, Manley GT. J Neurotrauma. 2018 Aug 24. PMID 29877132. <<PubMed>>

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Temporal lobe contusions on computed tomography are associated with impaired 6-month functional recovery after mild traumatic brain injury: A TRACK-TBI study.​

Yue JK, Winkler EA, Puffer RC, Deng H, Phelps RRL, Wagle S, Morrissey MR, Rivera EJ, Runyon SJ, Vassar MJ, Taylor SR, Cnossen MC, Lingsma HF, Yuh EL, Mukherjee P, Schnyer DM, Puccio AM, Valadka AB, Okonkwo DO, Manley GT; TRACK-TBI Investigators. Neurol Res. 2018 Nov;40(11):972-981. PMID 30175944. <<PubMed>>

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Testing a multivariate proteomic panel for TBI biomarker discovery: A TRACK-TBI Pilot study.

Huie JR, Diaz-Arrastia R, Yue JK, Sorani MD, Puccio AM, Okonkwo DO, Manley GT, Ferguson AR; TRACK-TBI Investigators. J Neurotrauma. 2019 Jan 1;36(1):100-110. PMID 30040754. <<PubMed>>

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Rehabilitation trajectories and outcomes in individuals with mild traumatic brain injury and psychiatric histories: A TRACK-TBI Pilot study.

Yue JK, Rick JW, Morrissey MR, Taylor SR, Deng H, Suen CG, Vassar MJ, Cnossen MC, Lingsma HF, Yuh EL, Mukherjee P, Gardner RC, Valadka AB, Okonkwo DO, Cage TA, Manley GT; TRACK-TBI Investigators. NeuroRehabilitation. 2018;43(2):169-182. PMID 30040754. <<PubMed>>

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Si B, Dumkrieger G, Wu T, Zafonte R, Valadka A, Okonkwo DO, Manley GT, Wang L, Dodick DW, Schwedt TJ, Li J. PLoS One. 2018 Jul 11;13(7):e0198741. <<PubMed>>

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Concordance of common data elements for assessment of subjective cognitive complaints after mild-traumatic brain injury: A TRACK-TBI Pilot Study.

Ngwenya LB, Gardner RC, Yue JK, Burke JF, Ferguson AR, Huang MC, Winkler EA, Pirracchio R, Satris GG, Yuh EL, Mukherjee P, Valadka AB, Okonkwo DO, Manley GT. Brain Inj. 2018;32(9):1071-1078. PMID 29863894. <<PubMed>> 

Seabury S, Gaudette E, Goldman D, Markowitz A, Brooks J, McCrea M, Okonkwo D, Manley G, and the TRACK-TBI Investigators. JAMA Netw Open. 2018 May 18;1(1):e180210. PMID 30646055. <<PubMed>>

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Age-related differences in diagnostic accuracy of plasma GFAP and Tau for identifying acute intracranial trauma on CT: A TRACK-TBI study.

Gardner RC*, Rubenstein R*, Wang KKW, Korley FK, Yue JK, Yuh EL, Mukherjee P, Valadka AB, Okonkwo DO, Diaz-Arrastia R, Manley GT; TRACK-TBI Investigators. J Neurotrauma. 2018 Oct 15;35(20):2341-2350. PMID 29717620. <<PubMed>>

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Performance evaluation of a multiplex assay for simultaneous detection of four clinically relevant TBI biomarkers.

Korley FK*, Yue JK*, Wilson D, Hrusovsky K, Diaz-Arrastia R, Ferguson AR, Yuh EL, Mukherjee P, Wang KKW, Valadka A, Puccio A, Okonkwo DO, Manley GT. J Neurotrauma. 2018 Jul 23. PMID 29690824. <<PubMed>>

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Traumatic brain injury-related symptoms reported by parents: Clinical, imaging, and host predictors in children with impairments in consciousness <24 hours.

Evans EA, Asuzu D, Cook N, Caruso P, Townsend E, Costine-Bartell B, Fortes-Monteiro C, Hotz G, Duhaime AC.​ J Neurotrauma. 2018 Jun 29. PMID 29681226. <<PubMed>>

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Medical device connectivity challenges outline the technical requirements and standards for promoting big data research and personalized medicine in neurocritical care.

Rodriguez A, Smielewski P, Rosenthal E, Moberg D. Mil Med. 2018 Mar 1;183(suppl_1):99-104. PMID 29635618. <<PubMed>>

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Optimizing outcome assessment in multicenter TBI trials: Perspectives from TRACK-TBI and the TBI Endpoints Development Initiative.

Bodien YG, McCrea M, Dikmen S, Temkin N, Boase K, Machamer J, Taylor SR, Sherer M, Levin H, Kramer JH, Corrigan JD, McAllister TW, Whyte J, Manley GT, Giacino JT; TRACK-TBI Investigators. J Head Trauma Rehabil. 2018 May/Jun;33(3):147-157. PMID 29385010. <<PubMed>>

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Functional status examination in patients with moderate-to-severe traumatic brain injuries.​

Machamer J, Temkin NR, Manley GT, Dikmen S. J Neurotrauma. 2018 May 15;35(10):1132-1137. PMID 29415608. <<PubMed>>

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Geriatric traumatic brain injury: Epidemiology, outcomes, knowledge gaps, and future directions.

Gardner R, Dams-O-Connor K, Morrissey MR, Manley GT. J Neurotrauma. 2018 Feb 15. Epub ahead of print. PMID 29212411. <<PubMed>>

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An update on diagnostic and prognostic biomarkers for traumatic brain injury.

Wang KK, Yang Z, Zhu T, Shi Y, Rubenstein R, Tyndall JA, Manley GT. Expert Rev Mol Diagn. 2018 Feb;18(2):165-180. PMID 29338452. <<PubMed>>

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Temporal profile of care following mild traumatic brain injury: Predictors of hospital admission, follow-up referral and six-month outcome.​

Yue JK*, Winkler EA*, Sharma S, Vassar MJ, Ratcliff JJ, Korley FK, Seabury SA, Ferguson AR, Lingsma HF, Deng H, Meeuws S, Adeoye OM, Rick JW, Robinson CK, Duarte SM, Yuh EL, Mukherjee P, Dikmen SS, McAllister TW, Diaz-Arrastia R, Gordon WA, Valadka AB, Okonkwo DO, Manley GT; TRACK-TBI Investigators. Brain Inj. 2017;31(13-14):1820-1829. PMID 29166203. <<PubMed>>

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Apolipoprotein E epsilon 4 (APOE-ε4) genotype is associated with decreased six-month verbal memory performance after mild traumatic brain injury.​

Yue JK, Robinson CK, Burke JF, Winkler EA, Deng H, Cnossen MC, Lingsma HF, Ferguson AR, McAllister TW, Rosand J, Burchard EG, Sorani MD, Sharma S, Nielson JL, Satris GG, Talbott JF, Tarapore PE, Korley FK, Wang KKW, Yuh EL, Mukherjee P, Diaz-Arrastia R, Valadka AB, Okonkwo DO, Manley GT; TRACK-TBI Investigators. Brain Behav. 2017 Aug 9;7(9):e00791. PMID 28948085. <<PubMed>>

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Emergency department blood alcohol level associates with injury factors and six-month outcome after uncomplicated mild traumatic brain injury.

Yue JK, Ngwenya LB, Upadhyayula PS, Deng H, Winkler EA, Burke JF, Lee YM, Robinson CK, Ferguson AR, Lingsma HF, Cnossen MC, Pirracchio R, Korley FK, Vassar MJ, Yuh EL, Mukherjee P, Gordon WA, Valadka AB, Okonkwo DO, Manley GT; TRACK-TBI Investigators. J Clin Neurosci. 2017 Nov;45:293-298. PMID 28789959. <<PubMed>>

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Comparing plasma phospho tau, total tau and phospho tau-total tau ratio as acute and chronic traumatic brain injury biomarkers.

Rubenstein R, Chang B, Yue JK, Chiu A, Winkler EA, Puccio AM, Diaz-Arrastia R, Yuh EL, Mukherjee P, Valadka AB, Gordon WA, Okonkwo DO, Davies P, Agarwal S, Fan L, Sarkis G, Yadikar H, Yang Z, Manley GT, Wang KKW; TRACK-TBI Investigators. JAMA Neurol. 2017;74(9):1063-1073. PMID 28738126. <<PubMed>>

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Validating multidimensional outcome assessment using the TBI Common Data Elements: An analysis of the TRACK-TBI Pilot sample.​

Nelson LD, Ranson J, Ferguson AR, Giacino JT, Okonkwo DO, Valadka AB, Manley GT, McCrea MA; TRACK-TBI Investigators. J Neurotrauma. 2017 Jun 8. Epub ahead of print. PMID 28595478. <<PubMed>>

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The Traumatic Brain Injury Endpoints Development (TED) Initiative: Progress on a public-private regulatory collaboration to accelerate diagnosis and treatment of traumatic brain injury.​

Manley GT, MacDonald CL, Markowitz AJ, Stephenson D, Robbins A, Gardner RC, Winkler EA, Bodien YG, Taylor SR, Yue JK, Kannan L, Kumar A, McCrea MA, Wang KKW; TED Investigators. J Neurotrauma. 2017 Mar 31. Epub ahead of print. PMID 28363253. <<PubMed>>

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Development of a prediction model for post-concussive symptoms following mild traumatic brain injury: A TRACK-TBI Pilot study.

Cnossen MC*, Winkler EA*, Yue JK, Okonkwo DO, Valadka AB, Steyerberg EW, Lingsma HF, Manley GT; TRACK-TBI Investigators. J Neurotrauma. 2017 Aug 18;34(16):2396-2409. PMID 28343409. <<PubMed>>

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Resting state functional connectivity alterations associated with six-month outcomes in mild traumatic brain injury.

Palacios EM, Yuh EL, Chang YS, Yue JK, Schnyer DM, Okonkwo DO, Valadka AB, Gordon WA, Maas AI, Vassar MJ, Manley GT, Mukherjee P. J Neurotrauma. 2017 Apr 15;34(8):1546-1557. PMID 28085565. <<PubMed>>

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Toward precision and reproducibility of diffusion tensor imaging: A multicenter diffusion phantom and traveling volunteer study.​

Palacios EM, Martin AJ, Boss MA, Ezekiel F, Chang YS, Yuh EL, Vassar MJ, Schnyer DM, MacDonald CL, Crawford KL, Irimia A, Toga AW, Mukherjee P; TRACK-TBI Investigators. AJNR Am J Neuroradiol. 2017 Mar;38(3):537-545. PMID 28007768. <<PubMed>>

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Mild traumatic brain injury: Longitudinal study of cognition, functional status, and post-traumatic symptoms.

Dikmen S, Machamer J, Temkin N. J Neurotrauma. 2017 Apr 15;34(8):1524-1530. PMID 27785968. <<PubMed>>

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DRD2 C957T polymorphism is associated with improved 6-month verbal learning following traumatic brain injury.

Yue JK*, Winkler EA*, Rick JW, Burke JF, McAllister TW, Oh SS, Burchard EG, Hu D, Rosand J, Temkin NR, Korley FK, Sorani MD, Ferguson AR, Lingsma HF, Sharma S, Robinson CK, Yuh EL, Tarapore PE, Wang KKW, Puccio AM, Mukherjee P, Diaz-Arrastia R, Gordon WA, Valadka AB, Okonkwo DO, Manley GT; TRACK-TBI Investigators. Neurogenetics. 2017 Jan;18(1):29-38. PMID 27826691. <<PubMed>>

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COMT Val158Met polymorphism is associated with post-traumatic stress disorder and functional outcome following mild traumatic brain injury.​

Winkler EA*, Yue JK*, Ferguson AR, Temkin NR, Stein MB, Barber J, Yuh EL, Sharma S, Satris GG, McAllister TW, Rosand J, Sorani MD, Lingsma HF, Vassar MJ, Tarapore PE, Burchard EG, Hu D, Eng C, Puccio AM, Wang KKW, Mukherjee P, Okonkwo DO, Diaz-Arrastia R, Manley GT; TRACK-TBI Investigators. J Clin Neurosci. 2017 Jan;35:109-116. PMID 27769642. <<PubMed>>

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Collaborative targeted maximum likelihood estimation for variable importance measure: Illustration for functional outcome prediction in mild traumatic brain injuries.

Pirracchio R, Yue JK, Manley GT, van der Laan MJ, Hubbard AE; TRACK-TBI Investigators. Stat Methods Med Res. 2016 Jun 29. Epub ahead of print. PMID 27363429. <<PubMed>>

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Screening for post-traumatic stress disorder in a civilian emergency department population with traumatic brain injury.

Haarbauer-Krupa J, Taylor CA, Yue JK, Winkler EA, Pirracchio R, Cooper SR, Burke JF, Stein MB, Manley GT; TRACK-TBI Investigators. J Neurotrauma. 2017 Jan 1;34(1):50-58. PMID 26936513. <<PubMed>>

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Plasma anti-glial fibrillary acidic protein autoantibody levels during the acute and chronic phases of traumatic brain injury - A transforming research and clinical knowledge in traumatic brain injury pilot study.

Wang KK*, Yang Z*, Yue JK*, Zhang Z, Winkler EA, Puccio AM, Diaz-Arrastia R, Lingsma HF, Yuh EL, Mukherjee P, Valadka AB, Gordon WA, Okonkwo DO, Manley GT; TRACK-TBI Investigators. J Neurotrauma. 2016 Jul 1;33(13):1270-7. PMID 26560343. <<PubMed>>

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COMT val (158) met polymorphism is associated with nonverbal cognition following mild traumatic brain injury.

Winkler EA*, Yue JK*, McAllister TW, Temkin NR, Oh SS, Burchard EG, Hu D, Ferguson AR, Lingsma HF, Burke JF, Sorani MD, Rosand J, Yuh EL, Barber J, Tarapore PE, Gardner RC, Sharma S, Satris GG, Eng C, Puccio AM, Wang KK, Mukherjee P, Valadka AB, Okonkwo DO, Diaz-Arrastia R, Manley GT; TRACK-TBI Investigators. Neurogenetics. 2016 Jan;17(1):31-41. PMID 26576546. <<PubMed>>

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Circulating brain-derived neurotrophic factor has diagnostic and prognostic value in traumatic brain injury.

Korley FK, Diaz-Arrastia R, Wu AH, Yue JK, Manley GT, Sair HI, Van Eyk J, Everett AD; TRACK-TBI Investigators. J Neurotrauma. 2016 Jan 15;33(2):215-25. PMID 26159676. <<PubMed>>

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Association of a common genetic variant within ANKK1 with six-month cognitive performance after traumatic brain injury.

Yue JK*, Pronger AM*, Ferguson AR, Temkin NR, Sharma S, Rosand J, Sorani MD, McAllister TW, Barber J, Winkler EA, Burchard EG, Hu D, Lingsma HF, Cooper SR, Puccio AM, Okonkwo DO, Diaz-Arrastia R, Manley GT; COBRIT Investigators; TRACK-TBI Investigators. Neurogenetics. 2015 Jul;16(3):169-80. PMID 25633559. <<PubMed>>

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Genetic data sharing and privacy.​

Sorani MD, Yue JK, Sharma S, Manley GT, Ferguson AR; TRACK-TBI Investigators. Neuroinformatics. 2015 Jan;13(1):1-6. PMID 25326433. <<PubMed>>

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Measurement of the glial fibrillary acidic protein and its breakdown products GFAP-BDP biomarker for the detection of traumatic brain injury compared to computed tomography and magnetic resonance imaging.

McMahon PJ, Panczykowski DM, Yue JK, Puccio AM, Inoue T, Sorani MD, Lingsma HF, Maas AI, Valadka AB, Yuh EL, Mukherjee P, Manley GT, Okonkwo DO; TRACK-TBI Investigators. J Neurotrauma. 2015 Apr;32(8):527-33. PMID 25264814. <<PubMed>>

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Outcome prediction after mild and complicated mild traumatic brain injury: External validation of existing models and identification of new predictors using the TRACK-TBI Pilot study.

Lingsma HF, Yue JK, Maas AI, Steyerberg EW, Manley GT; TRACK-TBI Investigators. J Neurotrauma. 2015 Jan;32(2):83-94. PMID 25025611. <<PubMed>>

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ED disposition of the Glasgow Coma Scale 13 to 15 traumatic brain injury patient: Analysis of the Transforming Research and Clinical Knowledge in TBI Study.

Ratcliff JJ, Adeoye O, Lindsell CJ, Hart KW, Pancioli A, McMullan JT, Yue JK, Nishijima DK, Gordon WA, Valadka AB, Okonkwo DO, Lingsma HF, Maas AI, Manley GT; TRACK-TBI investigators. Am J Emerg Med. 2014 Aug;32(8):844-50. PMID 24857248. <<PubMed>>

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Diffusion tensor imaging for outcome prediction in mild traumatic brain injury: A TRACK-TBI study.

Yuh EL, Cooper SR, Mukherjee P, Yue JK, Lingsma HF, Gordon WA, Valadka AB, Okonkwo DO, Schnyer DM, Vassar MJ, Maas AI, Manley GT; TRACK-TBI Investigators. J Neurotrauma. 2014 Sep;31(17):1457-77. PMID 24742275. <<PubMed>>

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Symptomatology and functional outcome in mild traumatic brain injury: Results from the prospective TRACK-TBI study.

McMahon P, Hricik A, Yue JK, Puccio AM, Inoue T, Lingsma HF, Beers SR, Gordon WA, Valadka AB, Manley GT, Okonkwo DO; TRACK-TBI Investigators. J Neurotrauma. 2014 Jan 1;31(1):26-33. PMID 23952719.<<PubMed>>

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Acute biomarkers of traumatic brain injury: Relationship between plasma levels of ubiquitin C-terminal hydrolase-L1 and glial fibrillary acidic protein.

Diaz-Arrastia R, Wang KK, Papa L, Sorani MD, Yue JK, Puccio AM, McMahon PJ, Inoue T, Yuh EL, Lingsma HF, Maas AI, Valadka AB, Okonkwo DO, Manley GT; TRACK-TBI Investigators. J Neurotrauma. 2014 Jan;31(1):19-25. PMID 23865516. <<PubMed>>

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The impact of previous traumatic brain injury on health and functioning: A TRACK-TBI study.

Dams-O'Connor K, Spielman L, Singh A, Gordon WA, Lingsma HF, Maas AI, Manley GT, Mukherjee P, Okonkwo DO, Puccio AM, Schnyer DM, Valadka AB, Yue JK, Yuh EL; TRACK-TBI Investigators. J Neurotrauma. 2013 Dec;30(24):2014-20. PMID 23924069. <<PubMed>>

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Transforming Research and Clinical Knowledge in Traumatic Brain Injury Pilot: Multicenter implementation of the common data elements for traumatic brain injury.

Yue JK, Vassar MJ, Lingsma HF, Cooper SR, Okonkwo DO, Valadka AB, Gordon WA, Maas AI, Mukherjee P, Yuh EL, Puccio AM, Schnyer DM, Manley GT; TRACK-TBI Investigators. J Neurotrauma. 2013 Nov;30(22):1831-44. PMID 23815563. <<PubMed>>

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Progress in developing common data elements for traumatic brain injury research: Version two--the end of the beginning.

Hicks R, Giacino J, Harrison-Felix C, Manley G, Valadka A, Wilde EA. J Neurotrauma. 2013 Nov 15;30(22):1852-61. PMID 23725058. <<PubMed>>

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GFAP-BDP as an acute diagnostic marker in traumatic brain injury: Results from the prospective Transforming Research and Clinical Knowledge in Traumatic Brain Injury study.

Okonkwo DO, Yue JK, Puccio AM, Panczykowski DM, Inoue T, McMahon PJ, Sorani MD, Yuh EL, Lingsma HF, Maas AI, Valadka AB, Manley GT; TRACK-TBI Investigators. J Neurotrauma. 2013 Sep;30(17):1490-7. PMID 23489259. <<PubMed>>

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Traumatic brain injury: An international knowledge-based approach.

Manley GT, Maas AI. JAMA. 2013 Aug 7;310(5):473-4. PMID 23925611. <<PubMed>>

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Magnetic resonance imaging improves 3-month outcome prediction in mild traumatic brain injury.

Yuh EL, Mukherjee P, Lingsma HF, Yue JK, Ferguson AR, Gordon WA, Valadka AB, Schnyer DM, Okonkwo DO, Maas AI, Manley GT; TRACK-TBI Investigators. Ann Neurol. 2013 Feb;73(2):224-35. PMID 23224915. <<PubMed>>

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Recommendations for the use of common outcome measures in traumatic brain injury research.

Wilde EA, Whiteneck GG, Bogner J, Bushnik T, Cifu DX, Dikmen S, French L, Giacino JT, Hart T, Malec JF, Millis SR, Novack TA, Sherer M, Tulsky DS, Vanderploeg RD, von Steinbuechel N. Arch Phys Med Rehabil. 2010 Nov;91(11):1650-1660.e17. PMID 21044708. <<PubMed>>

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Common data elements in radiologic imaging of traumatic brain injury.

Duhaime AC, Gean AD, Haacke EM, Hicks R, Wintermark M, Mukherjee P, Brody D, Latour L, Riedy G; Common Data Elements Neuroimaging Working Group Members, Pediatric Working Group Members. Arch Phys Med Rehabil. 2010 Nov;91(11):1661-6. PMID 21044709. <<PubMed>>

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Common data elements for research on traumatic brain injury and psychological health: Current status and future development.

Whyte J, Vasterling J, Manley GT. Arch Phys Med Rehabil. 2010 Nov;91(11):1692-6. PMID 21044713. <<PubMed>>

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Classification of Traumatic Brain Injury for Targeted Therapies

Saatman K, Duhaime AC, Bullock R, Maas A, Valadka A, Manley GT. Journal of Neurotrauma. 25:719–738 (July 2008). <<PubMed>>